Treatment Stuck? Try These Steps at Six Months & Beyond

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What to Do at Six or More Months of Treatment

Chronic Lyme can be very difficult to treat. To recover requires much more than antibiotics alone. When treatment is blocked at six months and beyond, the basic steps (Parts 1-11) in The Ross Lyme Support Protocol  may help and taking some or all of the additional steps discussed in this article. Take specific steps based on your own situation. 

Persister Lyme Infection Regimen

New research shows that Lyme can develop persisters. These are germ forms that go into hibernation and can ignore antibiotics. This condition can occur after someone is on antibiotics for some time. If you have tried antibiotics before and not gotten better, or if you are a year or more into treatment and not seeing good improvements, consider a persister Lyme regimen. For more information read How to Treat Persister Lyme. What Works?

If You Are Becoming More Allergic With Treatment

Chronic Infections can trigger excessive allergic reactions to food, prescription and natural medicines, and to the environment. If this is your problem, consider using supplements, diet and medicines for Mast Cell Activation Syndrome. For more information read Mast Cell Activation Syndrome & Lyme.

Three Months

My experience in chronic Lyme disease treatment shows that by three months of treatment 30% of people have improvement. Generally these people have an easier chance recovering from Lyme disease with traditional herbal and prescription antibiotic combinations. For those that are not having significant changes by three months then consider adding Biocidin. Based on unpublished lab experiments Biocidin breaks down biofilms and decreases antibiotic resistance by blocking efflux pumps that remove antibiotics from germs. Read more Biocidin: A Potent Antimicrobial & Biofilm Breaker.

Biocidin LSF.  Start at 1 pump under the tongue 1 time a day. Every 2 days increase by 1 pump first as 1 pump 2 times a day, then 1 pump 3 times a day, and eventually to 2 pumps 3 times a day. If you develop a herxheimer die-off reaction do not increase until it passes. For sensitive people place 1 pump in 5 ounces of water. Start with 1 ounce 1 time a day. Increase by 1 ounce a day increasing gradually at first to 1 ounce 3 times a day. Eventually as tolerated work up to 10 ounces (2 pumps) 3 times a day.

Six Months and Beyond

There are additional steps to consider by six to nine months of Lyme disease treatment if you are not having adequate improvement. Read or watch these following articles from Treat Lyme for more information and treatments.



Chronic viral infections

Boost energy, fix mitochondria cell energy factories


Continually review your symptoms to see if you have a coinfection that was missed. Treating Lyme is like peeling the layers of an onion. As you treat, it sometimes becomes more apparent which coinfections are present. In addition, it is possible to have coinfection relapses.

Autoimmune illness and chronic Inflammation


If you have a number of these symptoms: increased sugar cravings, intestinal gassiness or bloating, recent vaginal yeast infection, oral yeast, and/or vaginal or rectal itching consider treating for yeast overgrowth in the intestines.

Marty Ross MD Discusses What To Do When Your Treatment is Stuck

Here is a Lyme Byte about this topic recorded on 10/22/14 from Conversations with Marty Ross MD when Dr. Ross practiced in Seattle, Washington.

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The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

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About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS) and The Institute for Functional Medicine.

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