MTHFR and Detoxification. A Lyme Byte.

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Marty Ross MD on MTHFR & Lyme

Marty Ross MD discusses detoxification in chronic Lyme disease and the MTHFR defect. The recording is a Lyme Byte from our webinar Conversations with Marty Ross MD recorded May 21, 2013, when Dr. Ross practiced in Seattle, Washington.


  • Sign up for the next Conversations with Marty Ross MD.
  • Test for the MTHFR defect by having your physician order an MTHFR dna mutation analysis. Treat if there is at least one heterozygous defect or a homozygous defect.
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Treatment of MTHFR Detoxification Defect.

If a person has an MTHFR DNA mutation or if they are extremely sensitive to supplements and prescriptions consider treating for MTHFR defect using 5-MTHF and methylcobalamin combination. Once on a full dose, of this add 5-MTHF.

  • 5-MTHF 400 mcg and Methylcobalamin 400 mcg 1-3 pills 1 time a day. Start at 1 pill and increase every 7 days as tolerated up to 3 pills. Go slowly because opening up blocked detoxification with this supplement could cause more fatigue, body pain, and cognitive dysfunction.
  • 5-MTHF 1 mg or 5-MTHF 5 mg 1 pill daily. Add the 1 mg dose after you are stable on the 5 MTHF/Methylcobalamin combination above. Only add the 5mg dose if advised by your physician.


The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

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