MTHFR and Detoxification in Lyme Disease

Your source for quality supplements

Shop Now

MTHFR detoxification in Lyme disease by Marty Ross MD image

updated 6/26/20

Marty Ross MD on MTHFR & Lyme

In this video article, Marty Ross MD discusses MTHFR detoxification genetic defect in Lyme disease. Watch the video to learn: 

  • what the MTHFR genetic defect is,
  • how MTHFR defect can interfere with detoxification,
  • why it is not always necessary to correct for this defect,
  • how the gut microbiome can fix this problem even if you have a genetic defect,
  • when to take supplements to correct this problem. 

After you watch the video, see how to treat MTHFR in the section located below the video.

Video Thumbnail


Treatment of MTHFR Detoxification Defect

If a person has an MTHFR DNA mutation, also called a SNP,  and an elevated blood homocysteine level, consider treating for MTHFR defect using 5-MTHF and methylcobalamin combination. Once on a full dose of this add 5-MTHF.

  • 5-MTHF 400 mcg and Methylcobalamin 400 mcg 1-3 pills 1 time a day. Start at 1 pill and increase every 7 days as tolerated up to 3 pills. Go slowly because opening up blocked detoxification with this supplement could cause more fatigue, body pain, and cognitive dysfunction.
  • 5-MTHF 1 mg or 5-MTHF 5 mg 1 pill daily. Add the 1 mg dose after you are stable on the 5 MTHF/Methylcobalamin combination above. Only add the 5mg dose if advised by your physician.


The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

Marty Ross MD Image

Follow Marty Ross MD

See full profile: on LinkedIn.
See the latest: on Twitter, YouTube, and Instagram.

About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS), The Institute for Functional Medicine, and The American Academy of Anti-Aging Medicine (A4M).

keep up with our LATEST!

Subscribe to receive our FREE pdf download book: How to Successfully Treat Lyme: Key Info before You Treat or Treat Again & The Ross Lyme Support Protocol; health tips; updates; special offers; and more.