Biocidin: A Potent Antimicrobial & Biofilm Breaker

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Updated: 3/29/23

About Biocidin

Biocidin is a blend of herbs that is an essential natural medicine to mix with Lyme disease prescription or herbal antibiotics, such as Otoba Bark Extract and Cat’s Claw. Biocidin may even inhibit or kill Lyme on its own as a nutritional support. Its key herbal components may help in small intestinal bacterial overgrowth (SIBO), too.

According to unpublished laboratory experiments, Biocidin may

  • decrease and eliminate biofilms for Lyme, yeast, and a variety of other bacteria;
  • inhibit or kill all forms of Lyme including spirochete, cysts, and Lyme found in biofilms;
  • decrease drug resistance in Lyme by blocking efflux pumps that remove antibiotics from germs;
  • inhibit yeast;
  • decrease intestinal symptoms in (SIBO); and
  • may also support treatment of intestinal parasites.

Biocidin’s ingredients include a proprietary herbal blend of: Bilberry fruit extract, Grape seed extract, Shiitake mushroom extract, Goldenseal root, Noni fruit extract, Garlic bulb, White Willow bark, Milk Thistle seed, Raspberry fruit, Echinacea Purpurea plant extract, Echinacea Angustifolia root, Black Walnut hull, Black Walnut Walnut leaf, Lavender oil, Oregano oil, Galbanum oil, Tea Tree oil, Fumitory aerial parts extract, Gentian Lutea root.

In this article, I explain:

  • why to use Biocidin,
  • how it works, and
  • how to successfully use it in a Lyme disease treatment, SIBO, intestinal yeast overgrowth, or intestinal parasites.

Marty Ross, MD Speaks About Biocidin

This video was recorded during our free weekly Lyme Q&A Webinar Series called Conversations with Marty Ross MD in December 2017 Learn more or sign up for the next one here.

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The Four Big Reasons for Biocidin

There are four main reasons to use Biocidin as a nutritional support in Lyme disease. See the references at the end of this article for research supporting these claims.

1. May prevent and remove Lyme biofilms*

Biofilms block Lyme treatments. They are sugar slime layers held together in a protein skeleton that germs develop to hide from the immune system and to resist antibiotics. A number of studies show Lyme germs create biofilms, making it one reason the disease hard to treat. In research studies, the botanicals in Biocidin effectively weaken and eliminate biofilms in a number of ways. One way is by preventing germs from sticking to surfaces; another is to block quorum sensing where germs in biofilms talk to each other making the germs and biofilm stronger. Germs in biofilms use efflux pumps that flush antibiotics out; and research suggests many ingredients in Biocidin may block these pumps. Finally, several ingredients in Biocidin may limit germ swarming motility where some bacteria develop tails to rapidly spread. Learn more about biofilms and other effective treatments in Biofilms: Lyme Disease Gated Communities.

2. Limits Lyme drug resistance*

As I mentioned previously, bacteria in biofilms pump antibiotics out. Several ingredients of Biocidin may block these efflux pumps, which weakens biofilms. More importantly, however, blocking efflux pumps could prevent the removal of other antibiotics like doxycycline and Biaxin, which need to build up inside germs to kill them. Thus, using Biocidin in combination with some intracellular antibiotics—such as tetracyclines, macrolides (Biaxin and Zithromax), and quinolones (Cipro and Levaquin)—may help them work stronger, as it limits one form of antibiotic resistance.

3. Inhibits Lyme*

In-vitro laboratory experiments show spirochetes and cyst forms of Lyme are reduced or eliminated when exposed to various concentrations of Biocidin. Some of the herbs in Biocidin are potentially bacteriostatic, which means they work by limiting the growth of the germ. Additionally, some of the herbs are potentially bactericidal, which means they work by directly killing the germ. These laboratory experiments suggest Biocidin may work as a helpful nutritional support in Lyme disease..

4. Prevents and treats intestinal yeast overgrowth*

During a Lyme treatment with prescriptions and herbal antibiotics, the risk of intestinal yeast overgrowth increases. When it occurs, this condition can cause a devastating decline in health. In addition, at the beginning of treatment many people already suffer from yeast overgrowth, thereby adding to the burden of chronic Lyme disease. The herbs in Biocidin are shown to reduce or eliminate yeast and to remove yeast biofilms in laboratory experiments. To read more about yeast, see A Silent Problem. Do You Have Yeast?

How Biocidin for Chronic Lyme Disease Treatment Works*

Biocidin’s ingredients work together in a synergistic way to create the most benefit. The following are the proposed ways Biocidin works:

  • May Assist the Immune System. Based on research, shiitake and echinacea may boost the immune system. For instance, shiitake mushrooms in Biocidin improves the function of cells that fight infections as it boosts Th1 immunity.
  • Limits Quorum Sensing. Through quorum sensing, germs communicate to become stronger and to form biofilms. Also, the biofilms they form then become stronger. Garlic, oregano, and goldenseal found in Biocidin may limit quorum sensing.
  • Stops Biofilms Sticking to Surfaces. Raspberry, thyme, lavender, oregano, and tea tree oils found in Biocidin can limit biofilm adherence or sticking to surfaces.
  • Blocks Efflux Pumps. Black walnut, garlic, goldenseal, and raspberry found in Biocidin may limit germ antibiotic resistance. They can help block efflux pumps that remove herbal and prescription antibiotics from cells.
  • Limits Germ Swarming Motility. Bilberry and grape seed extract may decrease swarming where some bacteria grow tails to swim and rapidly spread.
  • Stops Germ Growth (Bacteriostatic Herbs). Echinacea, goldenseal, gentian, and shiitake mushrooms found in Biocidin may limit the ability of Lyme to grow.
  • Kills Germs Directly (Bactericidal Herbs). Biocidin contains volatile oils like lavender, oregano, and tea tree that research shows are naturally antimicrobial. Bilberry, black walnut, garlic, gentian, grape seed, olive leaf, and shiitake mushrooms are also bactericidal.

When to Use Biocidin

At the beginning of treatment and throughout care

Start Biocidin at the beginning of treatment when someone has failed previous Lyme treatments or has a difficult-to-treat illness. Biocidin may help to eliminate biofilms that block treatment. It can also help block the efflux pumps that remove herbal and prescription antibiotics from germs. Add it to regimens with prescription or herbal antibiotics for Lyme. Biocidin adds additional ingredients to these regimens, which could inhibit or remove germs and biofilms through different actions.

Three months into herbal or prescription antibiotic treatment

My experience in chronic Lyme disease treatment shows that by three months of treatment, 30 percent of people have improvement. Generally, these people have an easier chance of recovering from Lyme disease with traditional herbal and prescription antibiotic combinations. For those who are not having significant changes by three months, then consider adding Biocidin because it may help remove biofilms and decrease antibiotic resistance by blocking efflux pumps that remove antibiotics from germs.

Intestinal dysbiosis caused by yeast, SIBO, or parasites

Use Biocidin for people who have a disturbance in the healthy makeup of bacteria that live in the intestines. This is called dysbiosis. It can occur from yeast overgrowth in the intestines, parasites picked up from well water or international travel, or bacteria growing in the small intestines, which should not be there and is called small intestinal bowel overgrowth (SIBO). Common symptoms of these conditions include gassiness, bloating, constipation, or loose stools. Because Biocidin can help kill yeast, unhealthy bacteria, and parasites, I sometimes use it without testing for dysbiosis. I often use Biocidin in my patients based on dysbiosis symptoms alone. Basically, Biocidin can help in the clearance of many causes of dysbiosis. For more information about yeast treatments, see Kills & Prevents Yeast: A Brief Guide. For more information about treatments for intestinal parasites, see When & How to Treat Parasites in Lyme Disease. For more information about SIBO, see Small Intestine Bacterial Overgrowth (SIBO) in Lyme Disease.

Relapse prevention regimen

Some people at the end of treatment use low-dose prescription antibiotics or herbal antibiotics to prevent relapse. This can police the environment. Biocidin is useful in this situation because it seems to boost the immune system, helps eliminate biofilms, supports removal of germs, and does not lead to yeast overgrowth in the intestines. For further discussion about relapse and relapse prevention at the end of treatment, see Finished? And How to Prevent Relapse.

As a single antibiotic product regimen for Lyme disease

Laboratory experiments at The University of Jyväskylä, Finland, showed the herbs in Biocidin killed the various forms and life-cycle stages of Lyme and eliminated biofilms. As such, it may work on its own to kill Lyme. Based on these laboratory bench experiments, I added Biocidin as a stand-alone support supplement. My patients reported decreased symptoms from this addition. For other antibiotic herbal and prescription antibiotic options, see A Lyme Disease Antibiotic Guide.

How to Use Biocidin

For Lyme Disease, Use the Liposomal Formula

  • Biocidin LSF. Start at 1 pump under the tongue 1 time a day. Every 2 days increase by 1 pump first as 1 pump 2 times a day, then 1 pump 3 times a day, and eventually to 2 pumps 3 times a day. If you develop a Herxheimer die-off reaction, do not increase until it passes. For sensitive people, place 1 pump in 5 ounces of water. Start with 1 ounce of this sensitive person solution 1 time a day. Increase by 1 ounce a day, increasing gradually at first to 1 ounce 3 times a day. Eventually, as tolerated, work up to 10 ounces (2 pumps) 3 times a day.

Liposomal means Biocidin’s ingredients are microscopically wrapped in sunflower oil. This may allow for better absorption into the brain which is higher in fats than other tissues. Based on research, it also appears that the liposomal form concentrates more strongly in germs and cells than the non-liposomal form as the intracellular absorption is improved.

For Yeast, SIBO, Dysbiosis, and Intestinal Parasites

  • Biocidin Liquid. Start at 2 drops on the tongue 3 times a day and increase every other day by 1 drop per dose until you reach 10 drops 3 times a day. If you develop a Herxheimer die-off reaction, do not increase until it passes. Take without food by taking more than 30 minutes before food and more than 2 hours after food.
  • Biocidin Capsules. Start at 1 capsule 2 times a day and after 2 days increase to 1 capsule 3 times a day. Every 2 days add 1 capsule until you take 2 capsules 3 times a day. If you develop a Herxheimer die-off reaction, do not increase until it passes. Take without food by taking more than 30 minutes before food and more than 2 hours after food


The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


View Citations

  1. Fresco R. Biocidin: Clinical Protocols for Dysbiosis and Biofilms. Bio-Botanical Research. Published July 19, 2017. Accessed September 19, 2018. (View)
  2. Gilbert L. Preliminary report on activity of Biocidin against Borrelia species. [Unpublished manuscript]; 2016.
  3. Humphreys C. Biocidin Research Update - The Science Behind the Success. Bio-Botanical Research. Published July 19, 2017. Accessed September 19, 2018. (View)
  4. Lewis D. SIBO: Herbal Therapy is an Effective Treatment for Small Intestinal Bacterial Overgrowth (SIBO): A Clinical Research Case Study. Published April 19, 2017. Accessed July 26, 2020. (View)
  5. Marques C. Preliminary report on activity of Biocidin against multiple species of biofilms. [Unpublished manuscript]; 2013.Strand J. Botanical Solutions for Microbial Imbalances. Accessed December 1, 2022 (View)
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About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS), The Institute for Functional Medicine, and The American Academy of Anti-Aging Medicine (A4M).

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