Biocidin: A Potent Antimicrobial & Biofilm Breaker.

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Biocidin in Lyme disease treatment image from Marty Ross MD

Biocidin: A Potent Antimicrobial & Biofilm Breaker.

Biocidin is blend of herbs that is changing the way I approach my Lyme disease treatments. I consider it an essential natural medicine to mix with Lyme disease prescription or herbal antibiotics like otoba bark extract and cats claw. It can even kill Lyme on its own.

According to unpublished laboratory experiments which I have reviewed, Biocidin

  • decreases and eliminates biofilms for Lyme, yeast, and a variety of other bacteria,
  • kills all forms of Lyme including spirochete, cysts, and Lyme found in biofilms,
  • decreases drug resistance in Lyme by blocking efflux pumps that remove antibiotics from germs,
  • kills yeast,
  • decreases symptoms in small intestine bacterial overgrowth (SIBO), and
  • kills intestinal parasites.

Bicidin’s ingredients include: Bilberry extract (25% anthocyanosides), Noni, Milk Thistle, Echinacea (purpurea & angustifolia), Goldenseal, Shiitake, White Willow (bark), Garlic, Grapeseed extract (min. 90% polyphenols), Black Walnut (hull and leaf), Raspberry, Fumitory, Gentian, Tea Tree oil, Galbanum oil, Lavender oil (plant & flower), Oregano oil (plant & flower).

In this article I explain:

  • why I use Biocidin,
  • how it works, and
  • how to successfully use it in your Lyme disease treatment.

Marty Ross MD Speaks About Biocidin

This video was recorded during our free weekly Lyme Q&A Webinar Series called Conversations with Marty Ross MD. Learn more or sign up for the next one here.

The Big Four Reasons for Biocidin

There are four main reasons I use Biocidin in my Lyme disease treatments. See the references at the end of this article for research supporting these claims.

1. Prevents and removes Lyme biofilms. 

Biofilms block Lyme treatments. They are sugar slime layers held together in a protein skeleton that germs develop to hide from the immune system and to resist antibiotics. A number of studies show Lyme germs create biofilms and this is one reason the disease is hard to treat. Biocidin effectively weakens and eliminates biofilms in a number of ways. One way is by preventing germs from sticking to surfaces; another is to block quorum sensing where germs in biofilms talk to each other making the germs and biofilm stronger. Germs in biofilms use efflux pumps that flush antibiotics out. And Biocidin appears to block these pumps. Finally it limits germ swarming motility where some bacteria develop tails to rapidly spread. Learn more about biofilms and other effective treatments in: Biofilms: Lyme Disease Gated Communities.

2. Limits Lyme drug resistance. 

As I mentioned above, bacteria in biofilms pump antibiotics out. Biocidin blocks these efflux pumps which weakens biofilms. But more importantly this could prevent the removal of other antibiotics like doxycyline, and biaxin which need to build up inside germs to kill them. Thus using biocidin in combination with some intracellular antibiotics like the tetracyclines, macrolides (biaxin and zithromax), and quinolones (cipro and levaquin) may help them work stronger as it limits one form of antibiotic resistance.

3. Kills Lyme. 

Laboratory experiments show spirochetes and cyst forms of Lyme die when exposed to various concentrations of biocidin. Some of the herbs in biocidin are bacteristatic which means they work by limiting the growth of the germ. Some are bactericidal which means they work by directly killing the germ.

4. Prevents and treats intestinal yeast overgrowth. 

During a Lyme treatment with prescriptions and herbal antibiotics the risk of intestinal yeast overgrowth increases. This condition when it occurs can cause a devastating decline in health. In addition at the beginning of treatment many people already suffer from this condition which adds to the burden of chronic Lyme disease. Biocidin kills yeast and removes yeast biofilms. To read more about yeast see: A Silent Problem. Do You Have Yeast?

How Biocidin for Chronic Lyme Disease Treatment Works

Biocidin’s ingredients work together to create its benefit. Here are the proposed ways Biocidin works.

  • Boosts the Immune System. Shiitake and Echinacea boost the immune system. For instance, Shiitake mushrooms  in Biocidin improves the function of cells that fight infections as it boosts TH1 immunity.
  • Limits Quorum Sensing. Through quorum sensing germs communicate to becoming stronger. Also the biofilms they form become stronger. Garlic, oregano, and goldenseal found in Biocidin can limit quorum sensing.
  • Stops Biofilms Sticking to Surfaces. Raspeberry, thyme, lavender, oregano, and tea trea oils found in Biocidin can limit biofilm adherence or sticking to surfaces.
  • Blocks Efflux Pumps. Black walnut, garlic, goldenseal and raspberry found in Biocidin limit germ antibiotic resistance. They block efflux pumps that remove herbal and prescription antibiotics from cells.
  • Limits Germ Swarming Motility. Bilberry and grape seed extract decrease swarming where some bacteria grow tails to swim and rapidly spread.
  • Stops Germ Growth (Bacteristatic Herbs). Echinacea, goldenseal, gentian, and shiitake mushroom found in Biocidin limit the ability of Lyme to grow.
  • Kills Germs Directly (Bactericidal Herbs). Biocidin contains volatile oils like lavender, oregano, and tea tree that kill germs outright. Bilberry, black walnut, garlic, gentian, grape seed, olive leaf, and shiitake mushrooms are also bactericidal.

When to Use Biocidin

At the beginning of treatment and throughout care.

I recommend starting Biocidin at the beginning of treatment with me when someone has failed previous Lyme treatments or has a difficult to treat illness. I do this because it eliminates biofilms that block treatment. It also blocks the efflux pumps that remove herbal and prescription antibiotics from germs. I add it to regimens with prescription other prescription or herbal antibiotics for Lyme. Biocidin augments those germ killers by adding new germ killers in the Biocidin which kill through different action.

Three months into herbal or prescription antibiotic treatment.

My experience in chronic Lyme disease treatment shows that by 3 months of treatment 30% of people have improvement. Generally these people have an easier chance recovering from Lyme disease with traditional herbal and prescription antibiotic combinations. For those that are not having significant changes by 3 months then I am adding Biocidin to remove biofilms and to decrease antibiotic resistance by blocking efflux pumps that remove antibiotics from germs.

Intestinal dysbiosis caused by yeast, SIBO, or parasites.

I use biocidin for people who have a disturbance in the healthy makeup of bacteria that live in the intestines. This is called dysbiosis. It can occur from yeast overgrowth in the intestines, parasites picked up from well water or international travel, or bacteria growing in the small intestines which should not be there called small intestine bowel overgrowth (SIBO). Common symptoms of these conditions include gassiness, bloating, constipation, or loose stools. Because Biocidin can kill yeast, unhealthy bacteria, and parasites, I will use this without fully testing for the germs that lead to dysbiosis. It basically can kill any cause of dysbiosis. For more information about yeast treatments see Kills Yeast: A Brief Guide. For more information about treatments for intestinal parasites see Kills Parasites: A Brief Guide.

Relapse prevention regimen.

For some at the end of treatment I like to use low dose prescription antibiotics or herbal antibiotics to prevent relapse. I do this to police the environment. Biocidin is useful in this situation because it boosts the immune system, eliminates biofilms, kills germs, and does not lead to yeast overgrowth in the intestines. For further discussion about relapse and relapse prevention at the end of treatment see Finished? And How to Prevent Relapse.

As a single antibiotic regimen for Lyme disease.

According to laboratory experiments in Finland, Biocidin kills the various forms of Lyme and eliminates biofilms. As such it can work on its own to kill Lyme. Based on these laboratory bench experiments I am adding Biocidin as a stand alone treatment. For other antibiotic herbal and prescription antibiotic options see A Lyme Disease Antibiotic Guide.

How to Use Biocidin

For Lyme Disease Use The Liposomal Formula

Biocidin LSF.  Start at 1 pump under the tongue 1 time a day. Every 2 days increase by 1 pump first as 1 pump 2 times a day, then 1 pump 3 times a day, and eventually to 2 pumps 3 times a day. If you develop a herxheimer die-off reaction do not increase until it passes. For sensitive people place 1 pump in 5 ounces of water. Start with 1 ounce 1 time a day. Increase by 1 ounce a day increasing gradually at first to 1 ounce 3 times a day. Eventually as tolerated work up to 10 ounces (2 pumps) 3 times a day.

Liposomal means the biocidin is microscopically wrapped in fat. This allows for better absorption into the brain. It also appears based on research that the liposomal form concentrates more strongly in germs and cells than the non-liposomal form.

For Yeast, SIBO, Dysbiosis, and Intestinal Parasites

Biocidin Liquid. Start at 2 drops on the tongue 3 times a day and increase every other day by 1 drop per dose till you reach 10 drops 3 times a day. If you develop a herxheimer die-off reaction do not increase until it passes. Take without food by taking more than 30 min before food and over 2 hours after food.

Biocidin Capsules. Start at 1 capsule 2 times a day and after 2 days increase to 1 capsule 3 times a day. Every 2 days add 1 capsule till you take 2 capsules 3 times a day. If you develop a herxheimer die-off reaction do not increase until it passes. Take without food by taking 30 min before food and over 2 hours after food.

Where to Purchase Biocidin

Find all Bio-Botanical Research products like Biocidin at Marty Ross MD Supplements.


1. Humphreys, Corene. (2015) “Biocidin Research Update – The Science Behind the Success.” USA White Paper Webinar Series June 18, 2015. Retrieved from

2. Lewis, Danielle. (2017) “SIBO: Herbal Therapy is an Effective Treatment for Small Intestinal Bacterial Overgrowth (SIBO). A Clinical Research Update.” Retreived from

3. Fresco, Rachel. (2014) “Biocidin: Clinical Protocols for Dysbiosis and Biofilms.” Retreived from

4. Gilbert, Leona. (2016) “Analysis of the Activity of Biocidin Compounds against Borrelia.” Unpublished presentation of research  conducted by Dr. Gilbert’s lab in Finland provided through personal communication from Rachel Fresco LAc PhD.

5. Marques, C.  “Activity of Biocidin against biofilms microbial biofilms.” Unpublished manuscript of research conducted by Dr. Marques provided through personal communication with Rachel Fresco LAc PhD.

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