Leaky Gut Syndrome: A Treatment Guide

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Leaky Gut Syndrome in Lyme Disease Image

Leaky Gut Syndrome in Lyme Disease

In this video article I explain

  • the medical pathology of Leaky Gut Syndrome,
  • the causes of Leaky Gut Syndrome,
  • why Leaky Gut Syndrome leads to food allergies and inflammation, and
  • an approach to treat and fix Leaky Gut Syndrome.

Watch first, then read the details about my treatment recommendations in the area below the video. Note, there are limited studies in humans regarding whether treating leaky gut syndrome makes a real difference. However, in my practice, I find benefits for most of my patients when I treat Leaky Gut Syndrome.

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Leaky Gut Syndrome Treatments

On average it takes three to six months to repair and heal the gut. The following approach I discuss in the video is designed to restore intestinal function with a supportive diet and supplements. To heal one must weed out the causes like yeast and parasites, then seed the intestines with a healthy probiotic, and feed the healthy gut microbiome with a plant-heavy diet.

Weed Out the Causes of Leaky Gut

The two most common causes of Leaky Gut Syndrome in my Lyme disease practice are yeast overgrowth in the intestines and intestinal parasites. For more information about how to diagnose and treat these problems see


A healthy diet supports the lining of the intestines, decreases inflammation, and promotes a healthy gut microbiome (bacteria, viruses, parasites, yeast and fungi).

If you have a number of food sensitivities or allergies, follow an elimination diet to identify foods you should remove from your diet for six months while you heal your gut. After six months remain on a plant-forward diet that supports your intestinal lining and healthy gut microbiome like a plant-heavy paleo diet or a Mediterranean diet. If you do not need to follow the elimination diet, start with the plant-heavy paleo diet or a Mediterranean diet.

For more information see Elimination Diet to Find Food Problems and for a plant-forward paleo diet see The Best Brain, Inflammation, Pain, Energy, and Detox Diet Ever.


Except for the digestive enzymes, I recommend Thorne products for each of the supplements below.

  • L-Glutamine powder* 4 gm three times a day is a fuel source for injured intestinal cells that helps them repair.
  • Sacro B (Saccharomyces Boulardii)* 2 capsules one time a day is a healthy yeast that decreases intestinal inflammation and supports a healthy microbiome.
  • Vit D 5000 IU* one time a day helps to decrease intestinal inflammation.
  • Digestive Enzymes 2 pills before meals 3 times a day replaces digestive enzymes made by the pancreas which may not work correctly in leaky gut syndrome. I recommend Similase* by Integrative Therapeutics which I use with my patients. Consider using this if you have a lot of undigested food in your stool or if you are very gassy and bloated.


The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


View Citations

  1. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019;68(8):1516-1526. doi:10.1136/gutjnl-2019-318427 (View)
  2. Farré R, Fiorani M, Abdu Rahiman S, Matteoli G. Intestinal Permeability, Inflammation and the Role of Nutrients. Nutrients. 2020;12(4):1185. Published 2020 Apr 23. doi:10.3390/nu12041185 (View)
  3. Fasano A. All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Res. 2020;9:F1000 Faculty Rev-69. Published 2020 Jan 31. doi:10.12688/f1000research.20510.1 (View)
  4. Tsai YL, Lin TL, Chang CJ, et al. Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 2019;26(1):3. Published 2019 Jan 4. doi:10.1186/s12929-018-0493-6 (View)
  5. Terciolo C, Dapoigny M, Andre F. Beneficial effects of Saccharomyces boulardii CNCM I-745 on clinical disorders associated with intestinal barrier disruption. Clin Exp Gastroenterol. 2019;12:67-82. Published 2019 Feb 11. doi:10.2147/CEG.S181590 (View)
  6. Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clin Exp Immunol. 2008;153 Suppl 1(Suppl 1):3-6. doi:10.1111/j.1365-2249.2008.03713.x (View)
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About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS), The Institute for Functional Medicine, and The American Academy of Anti-Aging Medicine (A4M).

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