Key Oral Peptide Strategies to Repair and Restore in Lyme & Mold Toxicity

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How to Restore and Repair with Peptides in Lyme Disease Image

Updated: 12/17/22

Restore & Repair with Peptides

Peptide therapies are one of the newest types of supports some with Lyme disease and mold toxin illness are using. In this article, I discuss the current oral peptides that are available as supplements.

Injectable peptides are regulated by the FDA. Most of the injectable peptides are on a list the FDA has yet to rule on regarding which ones compounding pharmacies can continue to produce. Recently, the FDA has disallowed the production of some injectable peptides.

Due to the uncertainty of the FDA approval, injectable peptides are in a gray area of regulation. Without FDA approval, medical boards could choose to take negative action against providers using injectable peptides, even though these therapies have science supporting their safety and benefit. Thus, many providers, including me, choose to work with oral supplement peptides only, which do not require FDA production approval.

Marty Ross MD Discusses Peptides

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Oral Peptides

Peptides are short strands of amino acids. By comparison, long strands of amino acids of 40 or more are called proteins. Peptides occur naturally in our bodies. Some of these peptides have various healing properties. Below, I list the major peptides that are currently found in, or related to, oral products offered by Integrative Peptides. In addition, I include information about collagen peptides, which are found in Collagen Plus by Thorne.


Think of BPC-157 as the Swiss army knife of peptides. The key ingredient may:

  • promote healthy intestinal function,
  • improve leaky gut,
  • modulate healthy Th1 and Th2 immune function,
  • aid in tissue repair of joints, tendons, ligaments, and nerves,
  • promote healthy mitochondria (cell energy factory) function,
  • balance mast cell activation, and
  • have antimicrobial effects.


The key ingredient may:

  • promote healthy cognitive function and brain health,
  • repair brain injury due to stroke, infection, or trauma, and
  • promote healthy immune function in the brain.

Thymosin Beta 4 Active Fragment

The key ingredient may:

  • balance cytokine inflammation,
  • aid in tissue repair,
  • support healthy mitochondria (cell energy factory) function,
  • inhibit mast cell activation, and
  • have antimicrobial effects.


The key ingredient may:

  • balance cytokine inflammation,
  • stabilize mast cells, and
  • have antimicrobial effects.

Thymosin Alpha 1

The key ingredient may:

  • modulate the immune system to promote health levels of various immune cells,
  • promote healthy Th1 cellular immunity to fight bacteria and viruses, and
  • regulate inflammation.

Collagen Peptides

The key ingredient may:

  • enhance the health of skin, hair, nails, joints, tendons and ligaments,
  • promote elasticity of the skin and joint connective tissues,
  • reduce fine lines and wrinkles of the skin, and
  • help maintain the appearance of youthful skin.

DNF-10 Protein Hydrolysate

The key ingredient can decrease stomach production of the appetite peptide called ghrelin. Decreased ghrelin may:

  • promote weight loss,
  • suppress appetite, and
  • decrease gastric emptying causing a sense of fullness.

How to Use Oral Peptides in Lyme & Mold Toxicity

Here is the approach to peptides I am taking with my patients.

Start with BPC-157

A good place to start a peptide support program is to take BPC-157 500 mcg 1 pill 2 times a day. Over a month, a person can increase this up to 3 pills 2 times a day if needed, but usually 1 pill 2 times a day is enough.

I am finding this very helpful to repair tissues that are hurt by the inflammation of Lyme and mold toxicity illness. This is helping with joint area pains, nerve pain and numbness, and even brain function. In addition to repairing tissue, BPC-157 improves germ fighting as it balances healthy immune function between the germ-fighting Th1 cells and the autoimmune and allergy Th2 cells. Because BPC-157 supports mitochondrial function, this can help with energy. For those with mast cell activation, it may provide benefits, too. BPC-157 is also useful in repairing leaky gut syndrome and intestinal dysfunction.

Thymosin Beta 4 Active Fragment

After a month, if the benefits of the BPC-157 are not enough, consider adding thymosin beta 4 active fragment (TB4-FRAG) 135-300 1 pill 2 times a day for mast cell activation problems and to modulate cytokine inflammation. TB4-FRAG is found in TB4-FRAG and TB4-FRAG MAX by Integrative Peptides.


After a month of BPC-157, if you have significant symptoms of mast cell activation syndrome or inflammation, add KPV as 2 oral sprays 2 times a day. You can take this along with BPC-157 and TB4-FRAG. KPV is a stronger mast cell stabilizer than BPC-157 and TB4-FRAG.


After a month of BPC-157, consider adding Cerebrolysin if significant thinking problems remain. Cerbrolysin is found in CerbroPep by Integrative Peptides. Start at 1 pill a day and increase to 1 pill 2 times a day if needed. You can take this with other peptides.

Thymosin Alpha 1

Integrative Peptides has a product called Thymogen Alpha-1 aiming to have the effect of thymosin alpha 1. Thymogen Alpha-1 contains a synergistic combination of immune-modulating bioregulator dipeptides thymogen and immune peptide A2. Integrative Peptides claims the combination of thymogen and immune peptide A2 outperforms the immune modulating effects of Thymosin Alpha 1.

Take Thymogen Alpha-1 as 1 pill 2 times a day. Add this to a BPC-157 regimen to improve germ killing. A regimen using this could include taking BPC-157, Thymogen Alpha-1, and KPV or TB4-FRAG all at the same time.

Add Collagen Peptides

If a person needs skin support, has loose joints, or has injury to connective tissue in ligaments and tendons around joints, consider adding 1 scoop a day of Thorne’s Collagen Plus. Collagen Plus includes the collagen peptides I mention above.


The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, review the sitewide Terms & Conditions.


View Citations

  1. Holtorf K. Peptide Workshop. Lecture presented at the International Lyme and Associated Diseases Scientific Annual Conference; October 2021; Orlando, FL.
  2. Peptide Therapy Certification - Module I. Lectures presented at the Advanced Anti-Aging Medicine Conference; September 2022; Boston, MA.
  3. Peptide Therapy Certification - Module II. Lectures presented at the Advanced Anti-Aging Medicine Conference; December 2022; Las Vegas, NV.
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About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS), The Institute for Functional Medicine, and The American Academy of Anti-Aging Medicine (A4M).

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