Lufenuron: An Experimental Yeast Treatment.

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Lufenuron for Yeast in a Lyme disease treatment Image from Marty Ross MD

"I updated this article on August 15, 2018 to include references and informatin about the effect and safety of Lufenuron for treating yeast in Lyme disease." 

Marty Ross MD

Lufenuron for Yeast in Lyme Disease

Most patients with Lyme develop too many yeast in the intestines at some point in treatment. This even occurs using strong measures to prevent this problem. Unfortunately, yeast are becoming resistant to common anti-yeast medicines and herbs.

As a later resort, when yeast are a problem, there is an experimental treatment called Lufenuron which works relatively well. Here I describe how Lufenuron works, dosing, and safety issues.

Read more about yeast prevention in Prevent Yeast and Leaky Gut Syndrome. Take These Steps.  Find approaches to treat yeast overgrowth in Kills Yeast: A Brief Guide.

About Chitin and Yeast

Lufenuron is a chitin synthesis inhibitor. Chitin is a hard fibrous material found in insect coverings and yeast coverings. It is not found in humans. Yeast must make chitin to survive. If the production of chitin is blocked, the yeast eventually die because they develop holes in the covering.

Animal studies show it is effective against fungal infections. But there are no studies that show it works in humans.

Lufenuron for Yeast in Humans is Experimental

Lufenuron is manufactured as an insecticide and is found in flea treatments. There are numerous animal studies, including some on primates, cats and dogs, that show it is safe.

However because the treatment is very inexpensive, the pharmaceutical companies have not performed human safety studies. These companies stand to gain more profits from the sales of other prescription anti-yeast medications.

Even though human safety studies have not been conducted, lufenuron appears safe and is not toxic to the kidneys or liver. It is removed from the body in our stool.

Be aware, it is a fat soluble medicine. This means it is stored in fat. Substances that are stored in fat take a long time to remove from the body. Animal studies show, it can take a month or more to eliminate this medicine. So, if you have an allergic reaction, it could take a long time for the reaction to go away.

How to Take Lufenuron for Yeast in a Lyme Disease Treatment

When other common treatments for yeast overgrowth of the intestines fail, I find lufenuron to work about 85 to 90% of the time. However, because there are no human safety studies, I suggest using this medication for a limited period of time as I recommend below. I suggest taking it for no more than 2 months at a time.

Lufenuron is extremely fat soluble. This means it is stored in fatty tissues in our body and is slowly released over a 2 week period of time. An adult dosage is to take 3gm 1 time a day for 3 days and then take 11 days off. In treating intestinal yeast overgrowth I find that 4 rounds of treatment are often needed. Because it is stored and slowly released from fat a 3 day treatment lasts for 14 days.

It should be taken after a fatty meal. This increases its absorption. Common sources of fat include yogurt, avocado, oils, nuts and nut butters, butter, and cheeses.

How to Purchase Lufenuron

The older source for this medicine based in Switzerland is no longer available. I am now recommending an Australian source. You can find its products through the website: This source seems to work as well as the old source.

One Last Word

Because there are not human safety studies I consider this an experimental treatment. I include it as a later resort in yeast treatments. If you follow these recommendations you are doing so at your own risk. However, I do think it is safe. Read more about ways to eliminate yeast in Kills Yeast: A Brief Guide.

I have recommended it to hundreds of patients and had one major complication only. I did have a patient who developed an allergic reaction. Because the medication is fat soluble, lufenuron takes a long time to leave the body. it took over a month for the reaction to go away. In my patient we helped to remove the lufenuron using far infrared saunas and liver support to help with detox. Read more about this form of detox in Far Infrared Sauna Detox: More Than Sweat.


  1. Ben-Ziony Y, Arzi B. Use of lufenuron for treating fungal infections of dogs and cats: 297 cases (1997-1999). J Am Vet Med Assoc. 2000 Nov 15;217(10):1510-3.
  2. Chaffin WL, López-Ribot JL, Casanova M, Gozalbo D, Martínez JP. Cell wall and secreted proteins of Candida albicans: identification, function, and expression. Microbiology and Molecular Biology Reviews.1998;62(1):130-180.
  3. European Food Safety Authority (2008). EFSA Scientific Report (2008) 189, 1-130. Conclusion on the peer review of Lufenuron.

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