Update to The Ross Lyme Support Protocol

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The Ross Lyme Support Protocol 3rd Edition

The Ross Lyme Support Protocol is a living document. From time to time I update it based on the latest science and the experience I have treating people with tick-borne illnesses and mold toxicity in my Seattle clinic. This 3rd edition includes several major additions and subtractions which I lay out below. In addition to these major changes, there are numerous improvements throughout the document.

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What’s In

Action Steps for Persisters

See sections

  • [11] Lyme Infection
  • [12] Coinfections: Bartonella and Babesia.
  • [14] Special Considerations

When to Use Disulfiram for Lyme Persisters

See sections

  • [11] Lyme Infection
  • [14] Special Considerations.

Babesia and Bartonella Prescription Antimicrobials

The 2nd Edition included supplements but did not include suggested prescription antimicrobial regimens to start a treatment. I now include starting prescription antimicrobial options in [12] Coinfections: Bartonella and Babesia.


In section [10] Yeast, I now include probiotic regimens that include both human strains and spore-forming (soil-based) strains.

Fibrin Nests in Bartonella and Babesia Infections

See the Babesia and Bartonella section in [14] Special Considerations.

BPC-157 Peptide Therapy to Improve Th1 and Th2 Immune Balance

See [14] Special Considerations.

What’s Out

Biocidin LSF at Three Months

Earlier editions included a recommendation to add Biocidin LSF at three months of treatment if a person was not improving. Over-time, based on my clinical experience, I do not find this to be that helpful as a three-month addon supplement. As part of an anti-microbial approach, I still find Biocidin-LSF effective, so I continue to recommend it as an antimicrobial in my Lyme Disease Antibiotic Guide (treatlyme.net).

Low Dose Immunotherapy (LDI)

Earlier editions suggested trying low dose immunotherapy at six months at beyond if a person was having difficulty getting well. I see so few people that this helps—so I have removed this recommendation from [14] Special Considerations. You can read more in: LDI: Bring on The Regulators (treatlyme.net).

On The Horizon

There are two recent antibiotic discoveries that could change the course of Lyme disease treatment. One of these is Azlocillin and the other is Hygromycin A.

  • Azlocillin is an FDA approved antibiotic shown in laboratory experiments, including mouse experiments, to effectively treat persister phase and growth phase Lyme. You can read more about persisters in [11] Lyme Infection. There is one hitch—no pharmaceutical company currently produces this medication. This may change in the next couple of years as a company called FlightPath is working to bring this to market. While mouse experiments and other science experiments look promising, we will have to see what human studies eventually show.
  • Hygromycin A is a substance found in soil that targets Lyme spirochetes and does not appear to target other bacteria—so it should not disturb the intestinal microbiome. No experiments to date have been published that determine if it will also treat persister phase Lyme. FlighPath is also developing this novel therapeutic. However, because it is not US Food and Drug Administration (FDA) approved, it could take eight years or more to bring this to market. FlightPath must first perform the required laboratory and clinical studies to get FDA approval.


For many, chronic Lyme is a difficult illness. But for most, complete or varying degrees of recovery is possible. The Ross Lyme Support Protocol includes many steps and actions that I find helpful in my Seattle practice. If these ideas resonate with you, I encourage you to discuss them with your health care provider or physician to see if they are right for you. As always, I wish each of you well on your Lyme recovery journey.

Marty Ross, MD
Seattle USA
November 9, 2021

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About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS), The Institute for Functional Medicine, and The American Academy of Anti-Aging Medicine (A4M).

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