Too Tired? Try These Top Energizers

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Top energizers in Lyme disease by Marty Ross MD image.

Top Energizers in Lyme Disease

How would you like to have more energy to:

  • play with your children or grandchildren,
  • work in or out of your home,
  • create works of art,
  • exercise, or
  • enjoy the simple pleasures of life?

These top energizers support you to live your life more fully. Based on my experience treating people with chronic Lyme disease in my Seattle practice, these are the best fatigue busting supplements and pharmaceutical medicines.

There are multiple causes of fatigue that these natural and pharmaceutical medicines address. In addition to using these top energizers, be sure to follow all of the critical steps outlined in my Lyme disease treatment guidelines The Ross Lyme Support Protocol. For more information about fatigue and options to treat or support this problem see Energy & Fatigue.

1.  NT Factor Phospholipids*

  • How It Works: Repairs damaged mitochondria. Mitochondria are the energy factories found in every cell.
  • Who Should Use It: Anyone with fatigue that is not significantly improved after four to six months of a chronic Lyme disease treatment.
  • Effectiveness: Studies show average energy improvements of 40% by 2 months of use.
  • Type: Natural medicine.
  • Dosing: Take 2 pills 3 times a day with food for 2 months, then decrease to 1 pill 3 times a day.
  • Resources: Read more about NT Factor Phospholipids and mitochondria dysfunction.

2.  Ashwagandha*

  • How It Works: An adaptogen that corrects the damaging effects of physical and/or emotional stress on the adrenal and thyroid glands.
  • Who Should Use It: Anyone with fatigue especially at the very beginning of treatment but continuing throughout treatment.
  • Effectiveness: Based on my experience, improvements often occur within days to weeks.
  • Type: Natural medicine.
  • Dosing: Take 2 pills in the morning and 2 pills between 1-2 pm. Do not take too late in the day because it may keep you awake at night.
  • Resources: Read more about Ashwagandha.

3.  A Comprehensive Multi-Vitamin*

  • How It Works: Essential nutrients and minerals help the adrenal and thyroid glands, immune system, detoxification systems, and energy generating cell-based mitochondria to work more effectively.
  • Who Should Use It: Everyone. In chronic Lyme disease the body requires more essential nutrients and minerals than a diet provides.
  • Effectiveness: Based on my experience, improvements often occur within days to weeks.
  • Type: Natural medicine.
  • Dosing: Take one scoop daily of a vitamin powder like products from Thorne or Integrative Therapeutics.

4.  Stimulant: (Ritalin, Adderal, Dexedrine, Provigil, or Nuvigil)

  • How It Works: Stimulants increases the release of adrenalin (Ritalin, Adderal, and Dexedrine.) The exact mechanism of how Provigil and Nuvigil work is not known.
  • Who Should Use It: Consider using these if the natural medicine approaches do not work. However, these medications should be used with great caution. They do not correct the underlying problems created by chronic Lyme that lead to fatigue. Ritalin, Adderal, and Dexedrine are addictive. Provigil and Nuvigil are very expensive. Because of this insurance will often not approve these two medications for treating fatigue in chronic Lyme disease.
  • Effectiveness: Based on my experience these medicines improve energy within days, but often with side effects that are too stimulating.
  • Type: Prescription medicine.
  • Dosing: See your physician.
  • Resources: Read more at PDR.NET.

Where to Start

Start with the natural medicine options first. These options correct underlying problems while the prescription medicines will only mask them. The prescription medicines also tend to have more side effect problems and carry the risk of addiction or are quite costly.


The ideas and recommendations on this website and in this article are for informational purposes only. For more information about this, see the sitewide Terms & Conditions.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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About The Author

Marty Ross, MD is a passionate Lyme disease educator and clinical expert. He helps Lyme sufferers and their physicians see what really works based on his review of the science and extensive real-world experience. Dr. Ross is licensed to practice medicine in Washington State (License: MD00033296) where he has treated thousands of Lyme disease patients in his Seattle practice.

Marty Ross, MD is a graduate of Indiana University School of Medicine and Georgetown University Family Medicine Residency. He is a member of the International Lyme and Associated Disease Society (ILADS) and The Institute for Functional Medicine.

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