Lyme disease is hard to treat. While a majority of people with acute Lyme do get better following the standard 1 to 2 months of antibiotics recommended by The US Centers for Disease Control and Prevention and The Infectious Diseases Society of America, many do not. And if Lyme treatment starts more than a month or so after the acute infection, it appears harder to treat.
There are a number of reasons Lyme is hard to treat. One idea that is getting a lot of current attention is Lyme, like tuberculosis and leprosy, can develop persister cells. Persisters in Lyme are composed of the spirochetes, cysts, and biofilm communities that grow very slowly or not at all. These persisters forms essentially go into hibernation where they ignore the antibiotics a person takes. Faster growing Lyme is much easier to treat, but persisters evade the immune system and the antibiotics we send to poison them.
In this article I review a number of ways I treat persister Lyme. These treatment approaches are based on the ground breaking research of