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MTHFR and Detoxification. A Lyme Byte.

Marty Ross MD discusses detoxification in chronic Lyme disease and the MTHFR defect. The recording is a Lyme Byte from our webinar Conversations with MartyRoss MD recorded May 21, 2013.

If a person has an MTHFR genetic defect they are unable to produce adequate levels of glutathione. MTHFR is an enzyme that converts inactive folate into the active form called 5-methyltetrahydrofolate (5-MTHF). 5-MTHF and methylcobalamin (a methylated form of vitamin B12) are used in a process called methylation. Methylation is required to produce glutathione. An MTHFR dna mutation analysis blood test shows if a person has this problem. Another clue is having sensitivities to many different prescriptions or supplements.


  • Sign up for the next Conversations with Marty Ross MD.
  • Test for the MTHFR defect by having your physician order an MTHFR dna mutation analysis. Treat if there is at least one heterozygous defect or a homozygous defect.
  • Read a text summary of this article below the video.



Treatment of MTHFR Detoxification Defect.

If you have an MTHFR DNA mutation or are extremely sensitive to supplements and prescriptions use 5-MTHF and methylcobalamin. Once on a full dose of this add 5-MTHF.

  • 5-MTHF 400 mcg and Methylcobalamin 400 mcg 1-3 pills 1 time a day. Start at 1 pill and increase every 7 days as tolerated up to 3 pills. Go slowly because opening up blocked detoxification with this supplement could cause more fatigue, body pain, and cognitive dysfunction.
  • 5-MTHF 1 mg or5-MTHF 5 mg 1 pill daily. Add the 1 mg dose after you are stable on Methylguard. Only add the 5mg dose if advised by your physician.


by Marty Ross MD

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