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MTHFR and Detoxification. A Lyme Byte.

Note: This is an updated version of the article first published 05/27/13. To meet the requirements of federal law this article no longer includes supplement product names. The rest of the article is accurate and up to date.

     Marty Ross MD discusses detoxification in chronic Lyme disease and the MTHFR defect. The recording is a Lyme Byte from our webinar Conversations with Marty Ross MD recorded May 21, 2013. 


  • Sign up for the next Conversations with Marty Ross MD
  • Test for the MTHFR defect by having your physician order an MTHFR dna mutation analysis. Treat if there is at least one heterozygous defect or a homozygous defect.
  • Read a text summary of this article below the video.

     If a person has an MTHFR genetic defect they are unable to produce adequate levels of glutathione. MTHFR is an enzyme that converts inactive folate into the active form called 5-methyltetrahydrofolate (5-MTHF). 5-MTHF and methylcobalamin (a methylated form of vitamin B12) are used in a process called methylation. Methylation is required to produce glutathione. An MTHFR dna mutation analysis blood test shows if a person has this problem. Another clue is having sensitivities to many different prescriptions or supplements.

Treatment of MTHFR Detoxification Defect.

If you have an MTHFR DNA mutation or are extremely sensitive to supplements and prescriptions use 5-MTHF and methylcobalamin. Once on a full dose of this add 5-MTHF.

5-MTHF 400mg and Methylcobalamin 400mg 1-3 pills 1 time a day. Start at 1 pill and increase every 7 days as tolerated up to 3 pills. Go slowly because opening up blocked detoxification with this supplement could cause more fatigue, body pain, and cognitive dysfunction.
5-MTHF 1 mg or 5-MTHF 5 mg 1 pill daily. Add the 1 mg dose after you are stable on Methylguard. Only add the 5mg dose if advised by your physician.